What type of factors can affect the performance of this technology?

The accuracy and reliability of DNA-based testing are highly dependent on the integrity and concentration of the DNA extracted from the sample. Among all variables, sample quantity and quality are the most critical determinants of test performance.
Buccal swabs offer a convenient, non-invasive method for collecting genomic material. However, the effectiveness of this approach hinges on the number of epithelial cells successfully transferred from the inner cheek to the swab head. These cells are the primary source of genomic DNA, and insufficient collection can lead to low DNA yield, compromising downstream analysis.
When DNA concentration falls below the minimum threshold required for robust amplification, a phenomenon known as allelic dropout or test dropout may occur. This results in incomplete genotyping or partial disease screening, where some genetic markers may fail to amplify or be detected, leading to inconclusive or invalid results.
To mitigate this risk and ensure optimal sample integrity:
•     Follow the step-by-step collection instructions included in every kit.
•     Ensure the swab is rubbed firmly against the inner cheek for the full recommended duration.
•     Avoid eating, drinking, or brushing teeth for at least 30 minutes prior to collection.
Proper sample collection is essential for generating a comprehensive and accurate DNA profile, which underpins the validity of all subsequent analyses